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htslib — security advisory

Type: advisorySources: OSVAdvisory ID: UBUNTU-CVE-2026-31966

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. As one method of removing redundant data, CRAM uses reference-based compression so that instead of storing the full sequence for each alignment record it stores a location in an external reference sequence along with a list of differences to the reference at that location as a sequence of "features". When decoding CRAM records, the reference data is stored in a char array, and parts matching the alignment record sequence are copied over as necessary. Due to insufficient validation of the feature data series, it was possible to make the `cram_decode_seq()` function copy data from either before the start, or after the end of the stored reference either into the buffer used to store the output sequence for the cram record, or into the buffer used to build the SAM `MD` tag. This allowed arbitrary data to be leaked to the calling function. This bug may allow information about program state to be leaked. It may also cause a program crash through an attempt to access invalid memory. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Products
htslib
Affected versions
0.2.0~rc3-1, 0.2.0~rc3-1ubuntu0.1~esm1, 1.10.2-2ubuntu1, 1.10.2-2ubuntu2, 1.10.2-3, 1.10.2-3ubuntu0.1, 1.13+ds-2, 1.13+ds-2build1, 1.17+ds-1, 1.18+ds-1, 1.19+ds-1.1build2, 1.19+ds-1.1build3, 1.2.1-1, 1.2.1-2, 1.2.1-2ubuntu1, 1.2.1-2ubuntu1+esm1, 1.21+ds-1, 1.22.1+ds2-1, 1.22.1+ds2-1build1, 1.5-1, 1.5-4ubuntu1, 1.6-3ubuntu1, 1.6-4, 1.6-4build1, 1.7-2, 1.7-2ubuntu0.1~esm1, 1.9-10, 1.9-11, 1.9-12
Fixed versions
Not specified
CVEs
CVE-2026-31966
Confirmed fixed CVEs
Not specified
Updated in this feed
31 Oct 2026, 02:06 UTC · Revision 1

Source evidence

UBUNTU-CVE-2026-31966

core-osv · Original source

Published 18 Mar 2026, 20:16 UTC

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. As one method of removing redundant data, CRAM uses reference-based compression so that instead of storing the full sequence for each alignment record it stores a location in an external reference sequence along with a list of differences to the reference at that location as a sequence of "features". When decoding CRAM records, the reference data is stored in a char array, and parts matching the alignment record sequence are copied over as necessary. Due to insufficient validation of the feature data series, it was possible to make the `cram_decode_seq()` function copy data from either before the start, or after the end of the stored reference either into the buffer used to store the output sequence for the cram record, or into the buffer used to build the SAM `MD` tag. This allowed arbitrary data to be leaked to the calling function. This bug may allow information about program state to be leaked. It may also cause a program crash through an attempt to access invalid memory. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

osv:UBUNTU-CVE-2026-31966

htslib

Fixed versions: Not specified

htslib

Fixed versions: Not specified

htslib

Fixed versions: Not specified

htslib

Fixed versions: Not specified

htslib

Fixed versions: Not specified

htslib

Fixed versions: Not specified

htslib

Fixed versions: Not specified

htslib

Fixed versions: Not specified

htslib

Fixed versions: Not specified

Complete source record
{
  "id": "d2ebdb391dc85a45767019c993cc268640d05593e17463392e841035d07896e0",
  "url": "https://osv.dev/vulnerability/UBUNTU-CVE-2026-31966",
  "method": "structured",
  "payload": {
    "kind": "advisory",
    "title": "UBUNTU-CVE-2026-31966",
    "summary": "HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. As one method of removing redundant data, CRAM uses reference-based compression so that instead of storing the full sequence for each alignment record it stores a location in an external reference sequence along with a list of differences to the reference at that location as a sequence of \"features\". When decoding CRAM records, the reference data is stored in a char array, and parts matching the alignment record sequence are copied over as necessary. Due to insufficient validation of the feature data series, it was possible to make the `cram_decode_seq()` function copy data from either before the start, or after the end of the stored reference either into the buffer used to store the output sequence for the cram record, or into the buffer used to build the SAM `MD` tag. This allowed arbitrary data to be leaked to the calling function. This bug may allow information about program state to be leaked. It may also cause a program crash through an attempt to access invalid memory. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.",
    "evidence": "osv:UBUNTU-CVE-2026-31966",
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          },
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            ]
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        }
      ],
      "modified": "2026-10-17T12:58:08.908672898Z",
      "provider": "osv",
      "upstream": [
        "CVE-2026-31966"
      ],
      "references": [
        "https://ubuntu.com/security/CVE-2026-31966",
        "https://www.cve.org/CVERecord?id=CVE-2026-31966",
        "https://github.com/samtools/htslib/security/advisories/GHSA-5cj8-mj52-8vp3",
        "https://github.com/samtools/htslib/commit/22ec5230ef95769ab009420da69568c7e530af28",
        "https://github.com/samtools/htslib/commit/2a45eb129d703ad27f9fabc8169f0e94d3c69fa3",
        "https://github.com/samtools/htslib/commit/4a5ef25eb1fb3d64438103316fffe423b2c3f5f4"
      ]
    },
    "related_cves": [
      {
        "value": "CVE-2026-31966",
        "evidence": "/upstream"
      }
    ],
    "security_relevant": true,
    "severity_evidence": "/severity/1/score"
  },
  "source_id": "core-osv",
  "document_id": 358223,
  "published_at": "2026-03-18T20:16:00+00:00"
}