Critical
pymol — security advisory
PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.
- Products
- pymol
- Affected versions
- 1.7.2.1-2, 1.7.2.1-2.1, 1.7.2.1-2.1build1, 1.7.2.1-2.2, 1.8.4.0+dfsg-1build1, 2.2.0+dfsg-4, 2.2.0+dfsg-4build1, 2.3.0+dfsg-1, 2.3.0+dfsg-1build1, 2.4.0+dfsg-3, 2.4.0+dfsg-3build2, 2.5.0+dfsg-1, 2.5.0+dfsg-1build1, 2.5.0+dfsg-1build3, 2.5.0+dfsg-1build4, 2.5.0+dfsg-1build5, 2.5.0+dfsg-1build6, 3.1.0+dfsg-1, 3.1.0+dfsg-1build1, 3.1.0+dfsg-1build2, 3.1.0+dfsg-1build3, 3.1.0+dfsg-1build4
- Fixed versions
- Not specified
- CVEs
- CVE-2024-50636
- Confirmed fixed CVEs
- Not specified
- Updated in this feed
- 31 Oct 2026, 01:10 UTC · Revision 1
Source evidence
PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.
osv:UBUNTU-CVE-2024-50636
pymol
Fixed versions: Not specified
pymol
Fixed versions: Not specified
pymol
Fixed versions: Not specified
pymol
Fixed versions: Not specified
pymol
Fixed versions: Not specified
pymol
Fixed versions: Not specified
pymol
Fixed versions: Not specified
pymol
Fixed versions: Not specified
Complete source record
{
"id": "649ca9eb239f3a9c65a191ba632e6c1e416ccbf778a7bbdee658e748c6b56c01",
"url": "https://osv.dev/vulnerability/UBUNTU-CVE-2024-50636",
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"modified": "2026-10-17T12:56:39.469451597Z",
"provider": "osv",
"upstream": [
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"references": [
"https://ubuntu.com/security/CVE-2024-50636",
"https://www.cve.org/CVERecord?id=CVE-2024-50636",
"https://github.com/schrodinger/pymol-open-source/issues/405",
"https://github.com/yamerooo123/CVE/blob/main/CVE-2024-50636/Description.md",
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"source_id": "core-osv",
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"published_at": "2024-11-11T23:15:00+00:00"
}